“Impulsive-compulsive disorders: Neuropsychological and neurochemical basis”
Trevor W Robbins,
Dept. of Expt. Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, U.K.
The approach of defining ‘neurocognitive endophenotypes’ is applied to neuropsychiatric research with special reference to the constructs of impulsivity and compulsivity, and their possible cross-diagnostic significance. These constructs are characterized further according to principles in cognitive psychology and learning theory as well as their underlying neural and neurochemical substrates. They are applied to co-morbidities and commonalities across attention-deficit/hyperactivity disorder, substance dependence, obsessive-compulsive disorder and eating disorders, with implications for genetics, the future classification of psychiatric disorder and therapeutics.
Dalley, J.W., Everitt, B.J. & Robbins, T.W. (2011) Impulsivity, compulsivity, and top-down cognitive control. Neuron, 69, 680-694.